- Research & Pubs
Research & Pubs
Investigation of the fundamentals of stress response and genomic stability will be a major focus of the Institute, with two main research clusters:
• Oxidative/Metabolic Stress, DNA Damage/Repair, Biomarkers and Biosensors for Aging, Cancer and Other Diseases
Reactive oxygen species play a pivotal role in oxidative stress generated by environmental factors, drug therapy and metabolic disorders, with consequences to cell viability and genomic stability. Biomarkers and biosensors for exposure and response to the stress factors are highly relevant for aging, reproductive health, cancer biology, neurodegenerative disorders and other diseases.
• Transcription Response, Gene Function, Chromosome Structure (Anti-Infective and Anti-Cancer Agents)
Pathogens encounter multiple stress challenges in human hosts, including reactive oxygen species generated by the immune response, and action of antibiotics. Survival and adaptation of the pathogens requires rapid modulation of the genomic transcription profile and acquisition of resistance. Viability and proliferation of cancer cells following radiation and chemotherapy treatment also requires stress response and DNA repair functions. Experimental and computational studies of the biomolecular pathways for the signaling and transcription response can provide not only new mechanistic insights, but also potential targets for development of new therapeutics. Nanotechnology will be utilized for targeted drug delivery to enhance selectivity and overcome resistance.