- Research & Publications
Research & Publications
Investigation into the fundamentals of stress response and genomic stability is a major focus of the institute, with two main research clusters for achieving translational impact from basic discoveries:
Research Cluster 1
Oxidative/Metabolic Stress, DNA Damage/Repair, Biomarkers and Biosensors for Aging, Cancer and Other Diseases
Reactive oxygen species play a pivotal role in oxidative stress generated by environmental factors, drug therapy and metabolic disorders, with consequences to neural functions, cell viability and genomic stability. Biomarkers and biosensors for exposure and response to the various stress and environmental factors are highly relevant for identifying and utilizing personalized predictors that are relevant for human well-being and aging as well as for improving the treatment of cancer, neurological disorders, and other diseases.
Research Cluster 2
Pathogen Adaptations, Gene Function, Chromosome Structure (Anti-Infective and Anti-Cancer Agents)
Survival and growth of the pathogens in hosts requires adaptation to stress and environment through modulation of the genomic transcription profile and acquisition of resistance. Viability and proliferation of cancer cells following radiation and chemotherapy treatment also requires stress response and DNA repair functions. Experimental and computational studies of the biomolecular pathways for signaling and response can provide new mechanistic insights and identify targets for development of new therapeutics and control measures for drug resistant superbugs and mosquito-borne diseases. Nanotechnology is utilized in targeted drug delivery to enhance selectivity and overcome resistance.