2013-14

BSI Launch Event, presenting Distinguished Lecturer Philip C. Hanawalt, Ph.D.

Professor, Department of Biology, Stanford University
Friday, May 2, 2014 (AHC3, Rm. 110, 10am-12pm)

To view photos from the BSI Launch and AMSF Open House click here.

Image

Regulation of Eukaryotic DNA Replication and Repair Fidelity by Protein Acetylation: Potential for Influencing Aging

Friday, March 28, 2014, AHC3-205, 11am - 12pm

Robert Bambara, PhD, Professor, Department of Microbiology and Immunology and Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY

Nanotechnology and Cancer Therapeutics: Hype vs. Clinical Reality

Tuesday, March 4, 2014, AHC4-101, 1:30-2:30pm

Image
Jim Klostergaard, Ph.D., Professor, Department of Molecular and Cellular Oncology, University of Texas, M. D. Anderson Cancer Center

Dr. Klostergaard received his Ph.D. in Chemistry from the State University of New York, Buffalo, and carried out postdoctoral work in the Roswell Park Memorial Institute (Buffalo) and the University of California, Irvine. He has been an Assistant, Associate and Full Professor in the Departments of Tumor Biology, Cancer Biology, and Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, since 1982. Dr. Klostergaard is a translational investigator, interested in targeted cancer therapeutics and associated drug delivery platforms.

In recent years his work has focused on nanoparticles as vehicles for targeted delivery. Both passive and active tumor-targeting methods are being evaluated. This presentation will discuss underlying molecular, cellular and anatomical mechanisms that contribute to the exploitability of the Enhanced Permeability and Retention (EPR) effect for cancer drug delivery, and also examine possible strategies to enhance current outcomes.

Noncoding RNAs in the development of human skin cancer melanoma

Tuesday, February 18, 2014, MMC AHC4-101, 2-3pm

Image

Ranjan Perera, Scientific Director, Analytical Genomics and Bioinformatics, Sanford Burnham Medical Research Institute, Lake Nona, Orlando

UV damage recognition in chromatin and the DNA damage response

Friday, February 7, 2014, MMC AHC3-205, 11am-12pm

Feng Gong, Ph.D., Associate Professor, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine
This event will be cosponsored with the Department of Chemistry & Biochemistry.

Role of RNA Polymerase and Transcription in the Organization of the Bacterial Nucleoid

Friday, January 24, 2014 11:00am - 12:00pm, MMC, AHC3-205

Image

Ding Jin , Ph.D., Head, Transcription Control Section, Senior Investigator, Center for Cancer Research, National Cancer Institute

Recent advances in the cell biology of E. coli RNAP and the nucleoid have shown that the distribution of RNAP, which is coupled to cell growth, plays an important role in the nucleoid dynamic structure. Emerging evidence indicates that formation of the transcription foci centered at the putative bacterial nucleolus is critical in nucleoid remodeling and influencing global gene expression. The interface between the distribution of RNAP and nucleoid organization in the cell will be discussed.

Computational Molecular Dynamics: From Quantum Chemistry to Molecular Biophysics to Biology

Tuesday, January 14, 2014, 3-4:45pm, AHC-4, 101 (1st floor auditorium)

Image

This talk is given in honor of the Nobel Prize in Chemistry 2013, awarded to Martin Karplus, Arieh Warshel and Michael Levitt "for the development of multi-scale models for complex chemical systems." To acknowledge this award, a panel of six faculty from CEC (Computing and Information Sciences) and CAS (Physics, Chemistry & Biochemistry, and Biological Sciences) will be presenting on research at FIU, and elsewhere, aiming to stimulate new collaborations. This is an invitation to experimental scientists to join us in the discussion of collaborative, perhaps interdisciplinary, projects.

Keynote:
Introduction to Computational Structural Biology
Giri Narashiman, Professor, Associate Dean for Research & Graduate Studies, College of Engineering and Computing

Speakers:
Photochemically induced cold synthesis of complex organic molecules in astrochemical environments
Alexander Mebel, Professor, Chemistry & Biochemistry

Monte Carlo Computer Simulations of Proteins: Energy, Entropy, and Prion Diseases
Bernard Gerstman, Professor and Chair, Physics

Protein modeling to reveal function: A matter of appropriate scale
David Chatfield, Associate Professor and Chair, Chemistry & Biochemistry

Molecular Dynamics Simulations of Protein Dynamics and Aggregation
Prem Chapagain, Associate Professor, Physics

Computational Approaches to Understand and Engineer Proteins
Jessica Liberles, Assistant Professor, Biological Sciences

DNA Repair and Genome Stability

Thursday, December 12, 2013, AHC-2, Rm. 160

Yuan_Liu_presentation

Accelerating and Enhancing the Drug Discovery Process

November 22, 2013

Image

Richard A. Houghten, Ph.D. Founder, CEO & President, Torrey Pines Institute for Molecular Studies

Dr. Houghten's seminar will be cosponsored by Department of Chemistry & Biochemistry, College of Medicine, and the Biomolecular Sciences Institute.

Time: Friday November 22, 11 am

Location: College of Business Complex Room 155 (CBC-155) – MMC (live) Marine Sciences Building Room 105 (MSB-105) – BBC (via polycom)

Sponsored by the Department of Chemistry & Biochemistry, the Biomolecular Sciences Institute and the Herbert Wertheim College of Medicine.

Torrey Pines Institute has generated very large mixture-based combinatorial libraries that allow for high throughput screening of millions of compounds. Screening methods using disease-relevant animal models being developed at Torrey Pines Institute have the potential to revolutionize drug discovery by identifying individual compounds that are inherently more translatable to human diseases as well as identify compounds that are efficacious through previous unknown biological mechanisms or through multiple biological pathways. Dr. Houghten will describe the concepts of how the Torrey Pines libraries are synthesized, screened and deconvoluted to identify individual compounds.

Single Molecule Spectroscopy of Amino Acids and Peptides by Recognition Tunneling

November 14, 2013

Stuart Lindsay, Ph.D., specializes in biophysics at the molecular level and scanning probe microscopy. Much of his work is aimed at speedier diagnosis and an understanding of the molecular basis of disease. He holds 29 US patents and is a technology advisor for the Atomic Force Microscope Division of Agilent Technologies. Agilent has acquired Molecular Imaging Corporation, which he co-founded in 1993. Dr. Lindsay is the author of the first comprehensive text for nanoscience, "Introduction to Nanoscience" (OUP, 2009). He is a fellow of the American Association for the Advancement of Science and the American Physical Society.

Image

1st FIU-UM Bioinformatics & Computational Biology Research Day

October 9,2013

Image

Research Presentation: Mass Spectrometry Based Chemical Mapping

September 27,2013

Image: bsi-fernandez-lima-flyer-bsi-web3.jpg