Antibiotic resistance is one of the most serious health problems in the US and also in the world. The worst scenario is that, as the World Health Organization pointed out, “Over the last 30 years, no major new types of antibiotics have been developed” to combat antibacterial resistance pathogens. Dr. Fenfei Leng’s proposed research "Targeting transcription-coupled DNA supercoiling for discovering antibiotics against bacterial DNA gyrase" is to develop and utilize two novel high throughput screening assays to discover new types of antibiotics from the millions of compounds found in small molecule libraries that may target DNA gyrase and fight this urgent public health threat.
Congratulations Dr. Leng!
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