Dr. Fenfei Leng, Department of Chemistry and Biochemistry, recently had his research proposal entitled “Screening anticancer compounds targeting HMGA2-DNA interactions” accepted into the 2014 Florida Translational Research Program (FTRP) at Sanford-Burnham Medical Research Institute.
This research collaboration between Florida International University and Sanford-Burnham will focus on the mammalian high mobility group protein AT-hook 2 (HMGA2) is a DNA-binding protein associated with the formation of a variety of tumors including lung cancer, hepatocellular carcinoma, prostate cancer, oral cancer, and leukemia. These suggest that HMGA2 is a potential therapeutic target of anticancer drugs. The goal of this grant is to identify effective small molecule inhibitors for the treatment of cancers targeting HMGA2-DNA interactions. The significance of this research stems from its potential to provide drugs combatting human cancers.